Journal of Cell Biology. 2021 May 21; https://doi.org/10.1083/jcb.202012034

Opposing functions for retromer and Rab11 in extracellular vesicle cargo traffic at presynaptic terminals

Rylie B. Walsh, Agata N. Becalska, Matthew J. Zunitch, Tania Lemos, Erica C. Dresselhaus, So Min Lee, ShiYu Wang, Berith Isaac, Anna Yeh, Kate Koles, Avital A. Rodal

 

Proc Natl Acad Sci U S A. 2020 May 11; pii: 201917038. doi: 10.1073/pnas.1917038117. [Epub ahead of print]

TDP-43 dysfunction restricts dendritic complexity by inhibiting CREB activation and altering gene expression.

Herzog JJ, Xu W, Deshpande M, Rahman R, Suib H, Rodal AA, Rosbash M, Paradis S.

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Current Opinion in Neurobiology. Volume 63, August 2020, Pages 104-110. https://doi.org/10.1016/j.conb.2020.03.013

Mechanisms for biogenesis and release of neuronal extracellular vesicles.

Blanchette, CR., and Rodal, AA.

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Elife. 2020 Apr 14;9. pii: e51977. doi: 10.7554/eLife.51977. 

Retromer subunit, VPS29, regulates synaptic transmission and is required for endolysosomal function in the aging brain.
Ye H, Ojelade SA, Li-Kroeger D, Zuo Z, Wang L, Li Y, Gu JYJ, Tepass U, Rodal AA, Bellen HJ, Shulman JM.
 

bioRxiv. 2020 Mar 6; 981076; doi: https://doi.org/10.1101/2020.03.06.981076. [Epub ahead of print]

Autoregulation clamps the synaptic membrane-remodeling machinery and promotes productive actin-dependent endocytosis.

Del Signore SJ, Kelley CF, Messelaar EM, Lemos T, Marchan MF, Ermanoska B, Mund M, Kaksonen M, Rodal AA. 

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ACS Chem Biol. 2020 Mar 20;15(3):789-798. doi: 10.1021/acschembio.0c00053. 

The Impact of Sustained Immunization Regimens on the Antibody Response to Oligomannose Glycans

Nguyen DN, Redman RL, Horiya S, Bailey JK, Xu B, Stanfield RL, Temme JS, LaBranche CC, Wang S, Rodal AA, Montefiori DC, Wilson IA, Krauss IJ.

 

Nanoscale. 2019 Oct 10;11(39):18464-18474. doi: 10.1039/c9nr06570a.

Nanoparticles binding to lipid membranes: from vesicle-based gels to vesicle tubulation and destruction.

Zuraw-Weston S, Wood DA, Torres IK, Lee Y, Wang LS, Jiang Z, Lázaro GR, Wang S, Rodal AA, Hagan MF, Rotello VM, Dinsmore AD.

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J Cell Biol. 2019 Aug 5. pii: jcb.201811074. doi: 10.1083/jcb.201811074.

Higher-order assembly of Sorting Nexin 16 controls tubulation and distribution of neuronal endosomes.

Wang S, Zhao Z, Rodal AA.

 

J Cell Biol. 2019 Jul 1. pii: jcb.201906022. doi: 10.1083/jcb.201906022. 

The enemy of my enemy: PTEN and PLCXD collude to fight endosomal PtdIns(4,5)P2.

Del Signore SJ, Rodal AA.

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J Am Chem Soc. 2018 Mar 14;140(10):3505-3509. doi: 10.1021/jacs.7b13307.

Active Probes for Imaging Membrane Dynamics of Live Cells with High Spatial and Temporal Resolution over Extended Time Scales and Areas.

Wang H, Feng Z, Del Signore SJ, Rodal AA, Xu B.

 

Mol Ther. 2018 Feb 7;26(2):648-658. doi: 10.1016/j.ymthe.2017.11.020.

Cellular Uptake of A Taurine-Modified, Ester Bond-Decorated D-Peptide Derivative via Dynamin-Based Endocytosis and Macropinocytosis.

Zhou J, Du X, Berciu C, Del Signore SJ, Chen X, Yamagata N, Rodal AA, Nicastro D, Xu B.

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Sci Rep. 2017 Nov 15; doi:10.1038/s41598-017-15914-4
TDP-43 misexpression causes defects in dendritic growth.
Herzog JJ, Deshpande M, Shapiro L, Rodal AA, Paradis S.

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Angew Chem Int Ed Engl. 2017 Dec 18;56(51):16297-16301. doi: 10.1002/anie.201710269.

An in situ Dynamic Continuum of Supramolecular Phosphoglycopeptides Enables Formation of 3D Cell Spheroids.

Wang H, Shi J, Feng Z, Zhou R, Wang S, Rodal AA, Xu B.

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PLoS Genet. 2017 Oct 13;13(10):e1007052. doi: 10.1371/journal.pgen.1007052. 
dOCRL maintains immune cell quiescence by regulating endosomal traffic.
Del Signore SJ, Biber SA, Lehmann KS, Heimler SR, Rosenfeld BH, Eskin TL, Sweeney ST, Rodal AA.

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Nat Struct Mol Biol. 2016 Nov 4;23(11):956-957. doi: 10.1038/nsmb.3313.

The membrane strikes back: phosphoinositide binding regulates Skywalker function.

Del Signore SJ, Rodal AA.

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PNAS. 2016 September 20, doi:10.1073/pnas.1524412113

Coordinated autoinhibition of F-BAR domain membrane binding and WASp activation by Nervous Wreck.

Stanishneva-Konovalova TB, Kelley CF, Eskin TL, Messelaar EM, Wasserman SA, Sokolova OS, Rodal AA​.

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J Cell Biol. 2016 Sep 12;214(6):641-3.

Beyond the SNARE: Munc18-1 chaperones α-synuclein.

Deshpande M, Rodal AA.

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Mol Biol Cell. 2016 Aug 17. pii: mbc.E16-07-0519.

Role of BMP receptor traffic in synaptic growth defects in an ALS model.
Deshpande M, Feiger Z, Shilton AK, Luo CC, Silverman E, Rodal AA.

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Nat Methods. 2016 May;13(5):439-42. doi: 10.1038/nmeth.3804.
Quantitative super-resolution imaging with qPAINT.
Jungmann R, Avendaño MS, Dai M, Woehrstein JB, Agasti SS, Feiger Z, Rodal A, Yin P.

 

Cell Rep. 2015 Dec 10; S2211-1247(15)01359-5.
Membrane Charge Directs the Outcome of F-BAR Domain Lipid Binding and Autoregulation.
Kelley CF, Messelaar EM, Eskin TL, Wang S, Song K, Vishnia K, Becalska AN, Shupliakov O, Hagan MF, Danino D, Sokolova OS, Nicastro D, Rodal AA.

 

Biology Open 2015: doi: 10.1242/bio.016089
Tissue-specific tagging of endogenous loci in Drosophila melanogaster
Koles K,Yeh AR, Rodal AA.

 

Traffic. 2015 Nov 5. doi: 10.1111/tra.12345.
The crossroads of synaptic growth signaling, membrane traffic, and neurological disease: Insights from Drosophila.

Deshpande M, Rodal AA. 

 

Mol Biol Cell. 2015 Sep 15;26(18):3275-88.
The EHD protein Past1 controls postsynaptic membrane elaboration and synaptic function.
Koles K, Messelaar EM, Feiger Z, Yu CJ, Frank CA, Rodal AA. 

Cytoskeleton (Hoboken). 2015 May;72(5):207-24. 
Drosophila comes of age as a model system for understanding the function of cytoskeletal proteins in cells, tissues, and organisms.
Rodal AA, Del Signore SJ, Martin AC. 

Commun Integr Biol. 2015 Apr 29;8(2).
Assembly of actin filaments and microtubules in Nwk F-BAR-induced membrane deformations.
Kelley CF, Becalska AN, Berciu C, Nicastro D, Rodal AA. 

J Neurosci. 2013 Nov 6;33(45):17560-8.
New approaches for studying synaptic development, function, and plasticity using Drosophila as a model system.
Frank CA, Wang X, Collins CA, Rodal AA, Yuan Q, Verstreken P, Dickman DK. 

Mol Biol Cell. 2013 Aug;24(15):2406-18.
Formation of membrane ridges and scallops by the F-BAR protein Nervous Wreck.
Becalska AN, Kelley CF, Berciu C, Stanishneva-Konovalova TB, Fu X, Wang S, Sokolova OS, Nicastro D, Rodal AA. 

PLoS Genet. 2013 Apr;9(4):e1003450.
Drosophila cyfip Regulates Synaptic Development and Endocytosis by Suppressing Filamentous Actin Assembly.
Zhao L, Wang D, Wang Q, Rodal AA, Zhang YQ. 

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11884-9.
Structure and function of the interacting domains of Spire and Fmn-family formins.
Vizcarra CL, Kreutz B, Rodal AA, Toms AV, Lu J, Zheng W, Quinlan ME, Eck MJ. 

J Cell Biol. 2011 Apr 4;193(1):201-17.
A presynaptic endosomal trafficking pathway controls synaptic growth signaling.
Rodal AA, Blunk AD, Akbergenova Y, Jorquera RA, Buhl LK, Littleton JT. 

J. Neurosci. 2008 28(33):8316-25.
Nervous Wreck and Cdc42 cooperate to regulate endocytic actin assembly during synaptic growth. 
Rodal AA, Motola-Barnes RN, Littleton JT. 

Curr Biol. 2008 18(6): R259-261.
Synaptic endocytosis; illuminating the role of clathrin assembly.
Rodal AA, Littleton JT. 

Selected Earlier Publications

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Nature Struct Mol Biol. 2005 Jan;12(1):26-31.
Conformational changes in the Arp2/3 complex leading to actin nucleation.
Rodal AA, Sokolova O, Robins, DB, Daugherty KM, Hippenmeyer S, Riezman H, Grigorieff N, Goode BL. 

Mol Biol Cell. 2005 Jan;16(1):372-84.
Actin and septin ultra- structures at the budding yeast cell cortex.
Rodal AA, Kozubowski L, Goode BL, Drubin DG, Hartwig JH. 

Curr Biol. 2003 Jun 17;13(12):1000-8.
Negative regulation of yeast WASp by two SH3 domain-containing proteins.
Rodal AA, Manning AL, Goode BL, Drubin DG. 

J Cell Biol. 2001 Apr 30;153(3):627-34.
Activation of the Arp2/3 complex by the actin filament binding protein Abp1p.
Goode BL, Rodal AA, Barnes G, Drubin DG. 

J Cell Biol. 1999 Jun 14;145(6):1251-64.
Aip1p interacts with cofilin to disassemble actin filaments.
Rodal AA, Tetreault JW, Lappalainen P, Drubin DG, Amberg DC.